About:

The field of natural product chemistry in Brazil has contributed for over 70 years with valuable information published in several scientific articles on chemical structures produced by species of Brazilian biodiversity. Having a well-organized dataset allows research leaders, to perform specialized analyses, establish connections and discover trends that would not be possible without the compilation of data. Enabling continuous access to this information is important for the advancement of science and technology. Many initiatives, such as machine learning and Artificial Intelligence algorithms, also rely heavily on organized and good quality data. The Brazilian Biodiversity Natural Products Database allows scientists from all sectors to search the chemistry of natural bioactive compounds.

Data compilation in the BrNPDB has been carried out since 2010 in a cooperation between the University of São Paulo (USP) and the São Paulo State University (Unesp), pioneers in the development of the “NuBBE Database of Brazilian Biodiversity – NuBBEDB” the first version of this database [Valli et al., 2013; Pilon et al., 2017; http://nubbe.iq.unesp.br/portal/nubbedb.html]. With the continuation of this research, currently named BrNPDB, this is the most complete database on this content in Brazil. To cite BrNPDB or NuBBE DB , please reference:

Valli, M.; dos Santos, R.N.; Figueira, L.D.; Nakajima, C.H.; Andricopulo, A.D.; Bolzani, V.S. Development of a Natural Products Database from the Biodiversity of Brazil. Journal of Natural Products, 76(3), 439-444, 2013

Pilon, A. C.; Valli, M.; Dametto, A. C.; Pinto, M. E. F.; Freire, R. T.; Castro-Gamboa, I.; Andricopulo, A. D.; Bolzani, V. S. NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity. Scientific Reports, 7, 7215, 2017. BrNPDB is supported by Fapesp/DFG ptoject

do Carmo, P.R.V; Marcacini, R.; Valli, M.; Silva-Silva, J.V.; Ferreira, L.L.G.; Pilon, A.C.; Bolzani, V.S.; Andricopulo, A.D.; Marx, E. Development of a novel chemoinformatics tool for natural products databases. Future Drug Discovery, 5(2), 2023

This Database is part of the Unified Latin American Natural Product Database - LANaPDB Gómez-García, A.; Prinz, A.K.; Jiménez, D.A.A.; Zamora, W.J.; Barazorda-Ccahuana, H.L.; Chávez- Fumagalli, M.A.; Valli, M.; Andricopulo, A.D.; Bolzani, V.S.; Olmedo, D.A.; Solís, P.N.; Núñez, M.J.; Pérez, J.R.R.; Sánchez, H.A.V.; Hernández, H.F.C.; Martinez, O.M.M.; Koch, O.; Medina-Franco, J.L. Updating and profiling the natural product-likeness of Latin American compound libraries. Molecular Informatics, 43:e202400052, 2024

Gómez-García, A.; Jiménez, D.A.A.; Zamora, W.J.; Barazorda-Ccahuana, H.L.; Chávez-Fumagalli, M.Á.; Valli, M.; Andricopulo, A.D.; Bolzani, V.S.; Olmedo, D.A.; Solís, P.N.; Núñez, M.J.; Pérez, J.R.R.; Sánchez, H.A.V.; Hernández, H.F.C.; Medina-Franco, J.L. Navigating the Chemical Space and Chemical Multiverse of a Unified Latin American Natural Product Database: LANaPDB. Pharmaceuticals, 30(16), 1388, 2023